Historically, Republicans who have sought the Presidency have discovered that the first try does not work, and that the old saying–“If once you do not succeed, try, try again!”–applies.
Such is the case in the past 50 years with:
Richard Nixon, 1960 and 1968
Ronald Reagan 1968 and 1976, 1980
George H. W. Bush 1980 and 1988
Bob Dole 1980 and 1988, 1996
John McCain 2000 and 2008
Mitt Romney 2008 and 2012
So such potential candidates as Rick Santorum, Rick Perry, Mike Huckabee, Newt Gingrich, and Jon Huntsman all have history on their side, although it is unlikely to be of much help in their favor, except, possibly for Jon Huntsman, the only “mainstream” candidate of the group!