At least two Democrats who have served as Mayors of their cities are likely to enter the Democratic Presidential sweepstakes.
Los Angeles Mayor Eric Garcetti has spent his entire career in city government, serving on the LA City Council before his election as Mayor of the second largest city in 2013. He has had to deal with the issues facing nearly four million people, and has spent time in Iowa and New Hampshire, hinting of his plans to seek the Presidency. Garcetti has ties to the Jewish, Italian, and Mexican communities as he is ethnically related to all three groups.
Of course, California will also likely be the state that will contribute other potential nominees, including Senator Kamala Harris and Congressman Eric Swalwell, and potentially billionaire and liberal activist Tom Steyer, who has led the impeachment movement against Donald Trump.
Former New Orleans Mayor Mitch Landrieu offers the rare case of a Southerner who might be able to gain some traction, having served as Mayor from 2010-2018, after earlier service as Lieutenant Governor of the state, and as a member of the state House of Representatives. He is seen as a moderate, in the vein of Jimmy Carter and Bill Clinton in the past, but most observers would see him as more likely to be a potential Vice Presidential running mate to help a more progressive Presidential nominee.
The odds of Garcetti lasting longer in the Presidential competition than Landrieu seems likely, but at this early point, there is no way to know what the political future holds.